![]() Serum levels above the level of quantification were associated with an average decrease of FT3 level by 0.18 pg/mL (95% CI: 0.03 to 0.34, p = 0.020) for PBDE-99 and by 0.15 pg/mL (95% CI: 0.004 to 0.29, p = 0.045) for PBDE-100, compared with concentrations below the level of quantification. The effects of the individual PBDE congeners on the motor speed were consistent. ResultsĪ two-fold increase of the sum of serum PBDE’s was associated with a decrease of the number of taps with the preferred-hand in the Finger Tapping test by 5.31 (95% CI: 0.56 to 10.05, p = 0.029). In addition, we investigated the association between brominated flame retardants and serum levels of FT3, FT4, and TSH. Multiple regression models accounting for potential confounders were used to investigate the associations between biomarkers of internal exposure to brominated flame retardants and cognitive performance. ![]() Cross-sectional data on 515 adolescents (13.6-17 years of age) was available for the analysis. ![]() MethodsĪs a part of a biomonitoring program for environmental health surveillance in Flanders, Belgium, we assessed the neurobehavioral function with the Neurobehavioral Evaluation System (NES-3), and collected blood samples in a group of high school students. ![]() Although the first reports of detrimental neurobehavioral effects in rodents appeared more than ten years ago, human data are sparse. Animal and in vitro studies demonstrated a neurotoxic potential of brominated flame retardants, a group of chemicals used in many household and commercial products to prevent fire. ![]()
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